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README.md

Neural correlates of anesthesia in newborn mice and humans

Mouse ephys data for article "Neural correlates of anesthesia in newborn mice and humans". We provide ~200 Gb of data recorded from hippocampus and prefrontal cortex of 35 mice. Age is comprised between 8 and 10 postnatal days.

Channels:

- hippocampus: 5 channels are given, the reversal channel and two channels above/below. 
Channel 1 is the most superficial and channel 5 the deepest. 

- prefrontal cortex: 16 channels recorded with a 4x4 4-shank electrode. 
Channels 1 to 4 are the most medial ones and channels 13 : 16 the most lateral.
The probe spans from layer II to layer V/VI of the prelimbic section of the prefrontal cortex. 
Channels 1-5-9-13 are the most superficial, and 4-8-12-16 the deepest.

Anesthesia:

- urethane recordings: for these recordings, two .mat files per recording per area are provided. 
One is a 15 minutes recording without anesthesia (PFC and HP), and the second one is 45 minutes 
of recording after intraperitoneal injection of urethane.

- isoflurane recording: for these recordings, only one .mat file per area is provided. 
The length is 60 minutes. The first 15 minutes are without anesthesia. 
Anesthesia is then stepwise increased (1-2-3%) every 15 minutes.

More metadata about the mouse and recording (age, weight, sex, anesthesia etc.) can be found in the file Recording Metadata.xlsx.

Datacite.yml
Title Mouse ephys data associated with the paper *Neural Correlates of Anesthesia in Newborn Mice and Humans*
Authors Chini,Mattia;Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;http://orcid.org/0000-0002-5782-9720
Gretenkord,Sabine;Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Kostka,Johanna K.;Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Pöpplau,Jastyn A.;Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Cornelissen,Laura;Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Boston, MA, United States Department of Anesthesia, Harvard Medical School, Boston, MA, United States
Berde,Charles B.;Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Boston, MA, United States Department of Anesthesia, Harvard Medical School, Boston, MA, United States
Hanganu-Opatz,Ileana L.;Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Bitzenhofer,Sebastian H.;Developmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Description Electrophysiological recordings from prefrontal cortex and hippocampus CA1 area of 35 postnatal day 8-10 mice: - 19 mice without anesthesia (15 minutes) and bolus urethane anesthesia (45 minutes) - 16 mice without anesthesia (15 minutes) and isoflurane anesthesia (1-2-3%, 15 minutes each gradually increasing, for a total of 45 minutes)
License Creative Commons CC0 1.0 Public Domain Dedication (https://creativecommons.org/publicdomain/zero/1.0/)
References Neural Correlates of Anesthesia in Newborn Mice and Humans [] (IsPartOf)
Funding EU, ERC-2015-CoG 681577
DFG, Ha 4466/10-1
DFG, SFB 936 B5
DFG, SPP 1665
International Anesthesia Research Society
Keywords Neuroscience
Electrophysiology
Anesthesia
Neonatal Mice
Prefrontal cortex
Hippocampus
Resource Type Dataset