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@@ -7,9 +7,9 @@
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# if possible, including the prefix to indicate its type.
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authors:
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-
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- firstname: "Davide"
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- lastname: "Crombie"
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- affiliation: "LMU Munich"
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+ firstname: Davide
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+ lastname: Crombie
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+ affiliation: 'LMU Munich'
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id: "ORCID:0000-0003-3424-3249"
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-
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firstname: "Martin"
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@@ -31,21 +31,7 @@ authors:
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title: "Spiking activity in the visual thalamus is coupled to pupil dynamics across temporal scales"
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# Additional information about the resource, e.g., a brief abstract.
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-description: |
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- The processing of sensory information, even at early stages, is influenced by the internal state
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- of the animal. Internal states, such as arousal, are often characterized by relating neural activity
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- to a single “level” of arousal, defined by a behavioral indicator such as pupil size. In this study,
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- we expand the understanding of arousal-related modulations in sensory systems by uncovering multiple
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- timescales of pupil dynamics and their relationship to neural activity. Specifically, we observed a
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- robust coupling between spiking activity in the mouse dorsolateral geniculate nucleus (dLGN) of the
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- thalamus and pupil dynamics across timescales spanning a few seconds to several minutes. Throughout all
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- these timescales, two distinct spiking modes – individual tonic spikes and tightly clustered bursts of
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- spikes – preferred opposite phases of pupil dynamics. This multi-scale coupling reveals modulations
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- distinct from those captured by pupil size per se, locomotion, and eye movements. Furthermore, coupling
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- persisted even during viewing of a naturalistic movie, where it contributed to differences in the
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- encoding of visual information. We conclude that dLGN spiking activity is under the simultaneous
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- influence of multiple arousal-related processes associated with pupil dynamics occurring over a
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- broad range of timescales.
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+description: "Data and Python code for regenerating plots in Crombie et. al., (in revision)"
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# Lit of keywords the resource should be associated with.
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# Give as many keywords as possible, to make the resource findable.
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@@ -71,7 +57,7 @@ license:
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# Funding information for this resource.
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# Separate funder name and grant number by comma.
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funding:
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- - "DFG, RTG 2175 “Perception in context and its neural basis”
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+ - "DFG, RTG 2175, Perception in context and its neural basis”
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- "DFG, SFB 1233 TP 13, project number 276693517"
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- "DFG, SFB 870 TP 19, project number 118803580"
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- "LMU Munich, TU Munich and the Bavarian Ministry for Science and Art, ONE Munich Strategy Forum grant"
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