authors:
  -
    firstname: 'Tyler H.'
    lastname: Reekes
    affiliation: 'Louisiana State University Health Shreveport'
    id: 'ORCID:0000-0003-4131-1094'
  -
    firstname: 'Christina R.'
    lastname: Ledbetter
    affiliation: 'Louisiana State University Health Shreveport'
    id: 'ORCID:0000-0001-8581-6065'
  -
    firstname: Sibile
    lastname: Pardue
    affiliation: 'Louisiana State University Health Shreveport'
    id: 'ORCID:0000-0002-5133-7901'
  -
    firstname: 'J. Steven'
    lastname: Alexander
    affiliation: 'Louisiana State University Health Shreveport'
    id: 'ORCID:0000-0001-6975-3711'
  -
    firstname: 'Karen Y.'
    lastname: Stokes
    affiliation: 'Louisiana State University Health Shreveport'
    id: 'ORCID:0000-0002-7612-3467'
  -
    firstname: 'Mohammad Alfrad Nobel'
    lastname: Bhuiyan
    affiliation: 'Louisiana State University Health Shreveport'
    id: 'ORCID:0000-0002-6011-2624'
  -
    firstname: 'James C.'
    lastname: Patterson
    affiliation: 'Louisiana State University Health Shreveport'
    id: 'ORCID:0000-0001-5709-2557'
  -
    firstname: 'Katelyn T.'
    lastname: Lofton
    affiliation: 'Louisiana State University Health Shreveport'
    id: 'ORCID:0000-0001-9620-1162'
  -
    firstname: 'Christopher G.'
    lastname: Kevil
    affiliation: 'Louisiana State University Health Shreveport'
    id: 'ORCID:0000-0003-0863-7260'
  -
    firstname: 'Elizabeth A.'
    lastname: Disbrow
    affiliation: 'Louisiana State University Health Shreveport'
    id: 'ORCID:0000-0002-2133-3221'
title: 'Elevated Sulfides are associated with Cognitive Dysfunction and Brain Atrophy in Alzheimer''s Disease and Related Dementias'
description: "Emerging evidence indicates that vascular stress\nis an important contributor to the pathophysiology of Alzheimer's disease and related dementias (ADRD). Hydrogen sulfide (H2S) and its metabolites (acid-labile (e.g., iron-sulfur clusters) and bound (e.g., per-, poly-sulfides)) have been shown to regulate both vascular and neuronal homeostasis.  We recently reported that elevated plasma sulfides were associated with cognitive dysfunction and microvascular disease in ADRD; here we extend our previous work to show associations between elevated sulfides and magnetic resonance-based metrics of brain atrophy and white matter integrity. Elevated bound sulfides were associated with decreased measures of gray matter volume, while increased acid labile sulfides were associated with measures of decreased white matter integrity and increased ventricular volume. These findings are consistent with a ‘toxic’ sulfide model of ADRD. Our results are consistent with a compensatory sulfide response to oxidative stress."
keywords:
  - "Alzheimer's Disease"
  - 'hydrogen sulfide'
  - dementia
  - 'cortical thickness'
  - 'white matter integrity'
  - neuroimaging
license:
  name: 'Creative Commons CC0 1.0 Public Domain Dedication'
  url: 'https://creativecommons.org/publicdomain/zero/1.0/'
funding:
  - 'NIH, 3P2012130701A1S1'
  - 'NIH, HL149264-01A1'
references:
  -
    id: 'doi::tba'
    reftype: IsSupplementTo
    citation: 'Reekes, T. H., Ledbetter, C. R., Pardue, S., Alexander, J. S., Stokes, K. Y., Bhuiyan, M. A. N., Patterson, J. C., Lofton, K. T., Kevil, C. G., & Disbrow, E. A. (2023). Elevated Sulfides are associated with Cognitive Dysfunction and Brain Atrophy in Alzheimer’s Disease and Related Dementias. Submitted to Redox Biology.'
resourcetype: Dataset
templateversion: 1.2