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Add 'datacite.yml'

Julia Gamache 6 months ago
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datacite.yml

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+# Required fields
+# The main researchers involved working on the resource,
+# or the authors of the publication in priority order.
+# May be a corporate/institutional or personal name.
+# Include digital identifier (e.g., ORCID) if possible
+authors:
+  -
+    firstname: "Julia"
+    lastname: "Gamache"
+    affiliation: "N. Bud Grossman Center for Memory Research and Care, Department of Neurology, University of Minnesota, Minneapolis, MN 55414"
+    id: "0000-0002-3750-147X"
+  -
+    firstname: "Kellie"
+    lastname: "Benzow"
+    affiliation: "Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55414"
+  -
+    firstname: "Colleen"
+    lastname: "Forster"
+    affiliation: "Histology & Research Laboratory, Clinical and Translational Science Institute, University of Minnesota, Minneapolis, 55414"
+  -
+    firstname: "Lisa"
+    lastname: "Kemper"
+    affiliation: "N. Bud Grossman Center for Memory Research and Care, Department of Neurology, University of Minnesota, Minneapolis, MN 55414"
+  -
+    firstname: "Chris"
+    lastname: "Hlynialuk"
+    affiliation: "N. Bud Grossman Center for Memory Research and Care, Department of Neurology, University of Minnesota, Minneapolis, MN 55414"
+  -
+    firstname: "Eva"
+    lastname: "Furrow"
+    affiliation: "Veterinary Clinical Sciences (College of Veterinary Medicine), University of Minnesota, Minneapolis, MN 55414"
+  -
+    firstname: "Karen H."
+    lastname: "Ashe"
+    affiliation: "N. Bud Grossman Center for Memory Research and Care, Department of Neurology, University of Minnesota, Minneapolis, MN 55414"
+  -
+    firstname: "Michael D."
+    lastname: "Koob"
+    affiliation: "Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55414"
+    
+
+# A name or title to describe the published resource.
+title: Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice
+
+# Any additional information. It is best practice to supply a description for the resource.
+description: |
+  The tauopathy-like phenotype observed in the rTg4510 mouse line, in which human tauP301L expression
+  specifically within the forebrain can be temporally controlled, has largely been attributed to high overexpression
+  of mutant human tau in the forebrain region. Unexpectedly, we found that in a different mouse line with a
+  targeted-insertion of the same transgene driven by the same tetracycline-TransActivator (tTA) allele, but with
+  even higher overexpression of tauP301L than rTg4510, atrophy and tau histopathology are delayed, and a 
+  different behavioral profile is observed. This suggests that it is not overexpression of mutant human tau alone
+  that contributes to the phenotype in rTg4510 mice. Furthermore we show that the tauopathy-like phenotype
+  seen in rTg4510 requires a ~70-copy tau-transgene insertion in a 244kb deletion in Fgf14, a ~7-copy tTA-
+  transgene insertion in a 508kb deletion that disrupts another five genes, in addition to high transgene 
+  overexpression. We propose that these additional effects need to be accounted for in any studies using 
+  rTg4510, and that Tg-INDEL mutations and their impacts on phenotype should be defined for all transgenic 
+  models used in biomedical research.
+  
+# List of keywords the resource should be associated with.
+keywords:
+  - Neuroscience
+  - Transgene
+  - rTg4510
+  - Tau
+  - Fgf14
+
+# Any rights information for this resource. Please provide both a license name and a link to the license.
+# Please add also a LICENSE file to the repository
+license:
+  name: "Creative Commons CC0 1.0 Public Domain Dedication"
+  url: "https://creativecommons.org/publicdomain/zero/1.0/"
+
+## Optional Fields
+
+# Any funding reference for this resource. Separate funder name and grant number by comma
+funding:
+
+# Related publications. reftype might be: IsCitedBy, IsSupplementTo, IsReferencedBy, IsPartOf
+# for further valid types see https://schema.datacite.org/meta/kernel-4
+# Please provide digital identifier (e.g., DOI) if possible.
+references:
+
+# Type of the data in this repository (Dataset, Model, Software, Other see
+# https://schema.datacite.org/meta/kernel-4.1/doc/DataCite-MetadataKernel_v4.1.pdf
+# for examples
+dtype: Source Data