authors:
  -
    firstname: Bernhard
    lastname: Kodritsch
    affiliation: 'Helmholtz-Centre for Environmental Research GmbH---UFZ, Permoserstr. 15, 04318 Leipzig, Germany'
  -
    firstname: Florian
    lastname: Schunck
    affiliation: 'Osnabrück University, Barbarastr. 12, 49076 Osnabrück, Germany'
    id: 'ORCID:0000-0001-7245-953X'
  -
    firstname: Martin
    lastname: Krauss
    affiliation: 'Helmholtz-Centre for Environmental Research GmbH---UFZ, Permoserstr. 15, 04318 Leipzig, Germany'
    id: 'ORCID:0000-0002-0362-4244'
  -
    firstname: Andreas
    lastname: Focks
    affiliation: 'Osnabrück University, Barbarastr. 12, 49076 Osnabrück, Germany'
    id: 'ORCID:0000-0002-9031-0808'
  -
    firstname: Wibke
    lastname: Busch
    affiliation: 'Helmholtz-Centre for Environmental Research GmbH---UFZ, Permoserstr. 15, 04318 Leipzig, Germany'
    id: 'ORCID:0000-0002-5497-6266'
title: 'Survival, nrf2, internal concentration, and external concentration timeseries of zebrafish embryos exposed to Diuron, Diclofenac or Naproxen used in TKTD modelling'
description: 'The dataset contains a number of experiments generated during 2015--2022 at the Helmholtz Centre for Environmental Research---UFZ in Leipzig. The data describe observations of different endpoints measured in zebrafish embryos  (ZFE), exposed to the chemicals Diuron, Diclofenac and Naproxen (separately). The observed endpoints were external concentrations, internal body residues in the ZFE, gene expression of *nrf2* (a transcription factor that handles the stress response), and survival. The recommended way to work with this dataset is with the companion code, available under https://github.com/flo-schu/tktd_nrf2_zfe/.'
keywords:
  - 'TKTD modelling'
  - zebrafish
  - nrf2
  - 'internal concentration'
  - 'gene expression'
  - timeseries
  - survival
  - modelling
license:
  name: 'Creative Commons Attribution-ShareAlike 4.0'
  url: 'https://creativecommons.org/licenses/by-sa/4.0/deed.en'
funding:
  - null
references:
  -
    id: 'doi:tba'
    reftype: IsSupplementTo
    citation: 'Schunck F, Kodritsch B, Busch W, Kraus M, Focks A (2024)'
  -
    id: 'url:https://github.com/flo-schu/tktd_nrf2_zfe'
    reftype: IsReferencedBy
    citation: 'Analysis of scattered timeseries data from multiple experiments with pymob. Schunck 2024. Github'
resourcetype: Dataset
templateversion: 1.2