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["Positive allosteric modulation by TPA023B of various GABAARs in HEK293 cells transiently transfected with the respective GABAAR subunits"]
[]
[null,"I GABA potentiation (%)"]
[null,"α1β2γ2",null,"α2β3γ2",null,"α3β3γ2",null,"α5β2γ2"]
["conc TPA023B (nM)","mean","SEM","mean","SEM","mean","SEM","mean","SEM"]
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[null,null,null,"Lumbar DRG CULTURE"]
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["yellow","CTRL"]
["green","TPAO23B (8-11 min)"]
[null,null,null,"Tau W (ms)",{"$nulls":7},"Normalization tW",{"$nulls":7},"% change of Tau values normalized"]
["Sweep","ms","time (min)","CELL1","CELL2","CELL3","CELL4","CELL5","CELL6","CELL7",null,"CELL1","CELL2","CELL3","CELL4","CELL5","CELL6","CELL7",null,"CELL1","CELL2","CELL3","CELL4","CELL5","CELL6","CELL7"]
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[2,40,0.66666666666666663,164.486811015547,82.471395567937435,39.461867340997458,189.84918143084258,106.83181629712419,194.43993860688676,157.25673290985364,null,1.5193821507068102,0.9149409533273074,0.82980273293508655,{"$f":"G6/$G$15","v":1.3867700172201185},0.98344409062700833,{"$f":"I6/$I$15","v":1.2773662309603317},1.5615713720874089]
[3,60,1,102.17998692559391,73.210862770426431,60.179907280913611,127.91792262645302,103.35104250603358,155.86425598925356,95.972041118305427,null,0.94384739624825376,0.81220423294413113,1.26546093467811,{"$f":"G7/$G$15","v":0.93438769883802675},0.95140170349640985,1.0239446619912556,0.95300970049436162,null,{"$f":"AVERAGE(L30:L39)","v":1.385905614396864},1.5562124375346655,1.8368461161217684,1.555005928524219,1.4939642061120049,1.0492404307253458,1.1481897387238365,"TPA023B"]
[4,80,1.3333333333333333,80.849375077897278,51.724417244277959,55.795500011173395,124.20295657740201,83.641820647044682,159.64441365880054,65.84716378113643,null,0.7468142681515445,0.57383274889284941,1.1732657756580722,{"$f":"G8/$G$15","v":0.90725140310587316},0.76996775956559738,1.048778272767833,0.65386736701898363]
[5,100,1.6666666666666667,83.214696739102777,90.927273749420422,31.462856667029012,187.69702001549038,89.882776666307166,174.8385200158433,54.698467386560438,null,0.76866299566062202,1.0087508032917405,0.66159982300487008,{"$f":"G9/$G$15","v":1.3710493651712941},0.82741910252448303,1.1485954117217059,0.54315996006907674,null,{"$f":"(T7-T5)/T5*100","v":38.590561439686368},55.621243753466587,83.684611612176795,55.500592852421867,49.396420611200483,4.9240430725345785,14.818973872383644,"%change"]
[6,120,2,76.928675422754097,71.346447993046965,41.74823876404097,null,101.82152936530412,122.80690527825406,151.69110225726826,null,0.71059834884757156,0.79152034100722457,0.87788046932175579,null,0.93732171579309087,0.80677557735882666,1.5063042344973661]
[7,140,2.3333333333333335,116.35207551139936,88.825526212393754,40.4367772344984,89.897847073931388,98.39962246678968,105.72244794604065,101.45762195345274,null,1.0747564843542494,0.9854339322489023,0.85030310325466518,{"$f":"G11/$G$15","v":0.6566667182612046},0.9058212299391365,0.69453984520004719,1.0074819372815005]
[8,160,2.6666666666666665,160.7409745583999,79.890882404359019,43.065070422210631,100.53932391061574,83.98992671638257,null,73.095022769416474,null,1.4847814613426142,0.88631263731908416,0.90557075826126054,{"$f":"G12/$G$15","v":0.73439832028779517},0.77317226238758074,null,0.72583916050341601,null,{"$f":"AVERAGE(T9:Z9)","v":43.219492459124332},{"$f":"_xlfn.STDEV.S(T9:Z9)/SQRT(7)","v":10.088615783105185}]
[9,180,3,84.856437683740197,149.11467150372164,63.435380354730313,163.27578033764357,103.85022409667665,null,70.7452590444408,null,0.78382793120752647,1.6542841158582742,1.3339169058643281,{"$f":"G13/$G$15","v":1.1926622754122524},0.95599693741157954,null,0.70250582719427945]
[10,200,3.3333333333333335,127.02551954716884,122.85076871497417,76.949895091662739,67.860674055688435,114.52263542259286,null,161.94621279841641,null,1.1733482210071255,1.362911330298495,1.6180996376669678,{"$f":"G14/$G$15","v":0.49569425277220297},1.0542422000590104,null,1.6081382656534677]
[null,"AVG","Average",{"$f":"AVERAGE(D5:D14)","v":108.25901234855789},90.138489558281293,47.555721106650616,136.90026397557187,108.63028952567308,152.21941358251314,100.70415974624514]
[]
[1,220,{"$f":"B17/60","v":3.6666666666666665},93.091117927327318,115.40494516132021,73.377149657296059,62.277238504785146,null,165.61274615142858,null,null,{"$f":"D17/$D$15","v":0.85989254758398304},{"$f":"E17/$E$15","v":1.2803070666799032},{"$f":"F17/$F$15","v":1.5429720746476987},{"$f":"G17/$G$15","v":0.45490955748557016},null,{"$f":"I17/$I$15","v":1.0879870198794017}]
[2,240,4,92.360819410777566,142.19737976578205,121.38561147962078,64.843719945580006,91.874755500947757,null,61.139827349478864,null,0.85314670258958725,1.577543405293482,2.5524922901998668,0.47365664654343215,{"$f":"H18/$H$15","v":0.84575633464766375},null,{"$f":"J18/$J$15","v":0.60712315661576755}]
[3,260,4.333333333333333,113.32598164502357,230.14328068901847,25.59371773206631,133.94182579999259,91.392418413945492,140.83481509811293,81.30750716048172,null,1.0468041337764262,2.5532187394843531,0.53818377971114517,0.97838982855352874,0.84131616341081661,{"$f":"I19/$I$15","v":0.92520928693350279},0.80738975793413892]
[4,280,4.666666666666667,174.51001158364039,77.005801046919174,61.17672872465635,124.70771991080059,101.52701338252949,null,83.608856123281754,null,1.6119675193578933,0.8543054296148278,1.2864220602913086,0.91093849120008352,0.93461053842202235,null,0.83024232895602113]
[5,300,5,105.00998967768224,100.08541379054672,54.438987919233675,124.50386147527472,124.14099261529356,null,154.03493984086859,null,0.96998843236796883,1.1103515743497565,1.1447410879785911,0.90944938935611452,1.1427843298342195,null,1.529578720769893]
[6,320,5.333333333333333,70.608998602356621,183.87998856805604,53.384592160775149,138.98582842577898,116.57540863883645,null,100.67851481263129,null,0.65222282256759567,2.0399719306275244,1.1225692917378425,1.0152341886687615,1.0731390770277351,null,0.99974534384996139]
[7,340,5.666666666666667,123.19377492465001,135.58204580613011,45.012475777241605,89.26880513646681,75.056285793304625,100.63177610129739,54.238791779029164,null,1.1379539887913181,1.5041526263701828,0.94652072831141776,0.65207182619016502,0.69093331262424962,{"$f":"I23/$I$15","v":0.66109685836326137},0.53859534616743088]
[8,360,6,75.725273369847926,294.85343400560015,25.216389931341801,298.57337704626656,103.7276612364733,143.10209606641629,125.28776985546364,null,0.6994823962187815,3.2711157625395453,0.53024934423327075,2.1809554516238423,0.95486868063588171,{"$f":"I24/$I$15","v":0.94010410826372914},1.2441171265533062]
[9,380,6.333333333333333,77.485011311501353,72.847143377103293,81.148958333333326,327.38127807640029,100.39351953530715,162.25283475765221,79.503682564654696,null,0.71573728256475755,0.80816911548093062,1.706397389103721,2.3913852944419256,0.92417612043260455,{"$f":"I25/$I$15","v":1.0659142019996042},0.78947764188677494,null,"% change of Tau values "]
[10,400,6.666666666666667,159.83792271674182,75.348422750533345,58.490647105645017,372.08665685067092,93.424441627483574,87.671265901964787,105.95794451707522,null,1.4764398755284875,0.83591840865954314,1.2299392322213187,2.7179396594667273,0.86002202549045181,{"$f":"I26/$I$15","v":0.57595324957970018},1.0521704841594288,null,"CELL1","CELL2","CELL3","CELL4","CELL5","CELL6","CELL7"]
[11,420,7,120.42750627889492,51.359386440859346,55.959165153996146,73.464128864548741,89.473833418543194,null,104.30516769980098,null,1.1124016713837972,0.5697830825937199,1.1767073204189162,0.53662518048655838,0.82365456088927613,null,1.0357582840930273,null,{"$f":"AVERAGE(D5:D14)","v":108.25901234855789},90.138489558281293,47.555721106650616,136.90026397557187,108.63028952567308,152.21941358251314,100.70415974624514,"CTRL"]
[12,440,7.333333333333333,184.88138390953901,67.090424920324239,144.45387887733975,184.91005931606404,63.364506763021964,183.15572625821414,100.68695699170259,null,1.7077689875304114,0.74430385120825937,3.0375709907411754,1.3506917660075433,0.5833042242610128,{"$f":"I28/$I$15","v":1.2032350010265376},0.99982917533311533,{"$nulls":10},"ttest"]
[13,460,7.666666666666667,128.07172630779897,90.047318745104349,119.18258135319812,257.02060197598911,90.0422962962963,null,104.08999647856615,null,1.1830121440185575,0.99898854736058118,2.5061670516132826,1.877429557198306,0.82888756616096659,null,1.0336216174272508,null,{"$f":"AVERAGE(D30:D39)","v":150.03677302292581},140.27463855118589,87.352541614121193,212.88072209854485,162.28976425093941,159.71476307207564,115.62748286744467,"TPA023B",null,{"$f":"TTEST(T27:Z27,T29:Z29,2,1)","v":3.7155689419881817E-3}]
[14,480,8,266.16613113420925,105.79896084085773,100.78271607669616,155.47160010745952,194.59486416605725,200.45276573038979,246.5239953203496,null,2.4586048344616627,1.1737378933163813,2.1192553436562611,1.1356559556028429,1.7913499541954896,{"$f":"I30/$I$15","v":1.3168672839600117},2.4480021077733238]
[15,500,8.3333333333333339,139.73663948816713,177.14753407483479,101.21934074127176,null,null,149.55112421819626,76.290319070908652,null,1.290762186507501,1.9652818118312891,2.1284366714632017,null,null,0.98247076833684899,0.7575686968953953,null,{"$f":"(T29-T27)/T27*100","v":38.590561439686404},55.621243753466509,83.684611612176852,55.500592852421917,49.396420611200483,4.9240430725345803,14.818973872383619,"%change"]
[16,520,8.6666666666666661,108.04640019223052,96.076947637310127,116.71892810408058,271.15857699738814,90.492965311651176,231.8068784066499,209.91988007421816,null,0.99803607892114488,1.0658814908939558,2.4543614393381064,{"$f":"G32/$G$15","v":1.9807016372574195},{"$f":"H32/$H$15","v":0.83303621583614185},1.5228470071657123,2.0845204468531922]
[17,540,9,130.42647017876035,89.030490544846543,84.358642167723929,130.75991364367738,153.40061414526025,101.76479272128232,73.251395631141122,null,1.2047631633552194,0.98770781473192593,1.7738905058034429,0.95514727179057768,{"$f":"H33/$H$15","v":1.4121348181531488},0.66854017057501647,0.72739195496710729]
[18,560,9.3333333333333339,92.143531593145553,219.49508331744863,78.519521982038412,331.0989221103066,105.01156646443822,166.38764118912295,69.305507369995695,null,0.85113959193045408,2.4350872129439067,1.6511056956942567,2.4185411517496198,{"$f":"H34/$H$15","v":0.96668771594887781},1.0930776651489968,0.6882089830711271,null,{"$f":"AVERAGE(T31:Z31)","v":43.219492459124332},{"$f":"_xlfn.STDEV.S(T31:Z31)/SQRT(7)","v":10.088615783105189}]
[19,580,9.6666666666666661,115.22015033373215,308.65441763941357,68.220884256294298,202.93017252764082,null,125.73710008537518,89.565799012622492,null,1.0643007712167345,3.4242244256805008,1.4345463104912035,1.4823212653837625,null,0.82602538747278265,0.88939522695299633]
[20,600,10,142.67775835348658,112.0240687908408,94.992276040152291,131.86703540544264,289.93662298620387,119.35701758706591,null,null,1.3179296139716463,1.242799489317034,1.9974941779795181,0.96323433992043028,{"$f":"H36/$H$15","v":2.6690219114042026},0.78411166340728544]
[1,620,10.333333333333334,143.6866830408018,83.701739500667188,88.455306860637847,268.31916238867512,154.60634622394031,165.33674373811598,108.57869550130893,null,1.3272491585105046,0.92859043801202967,1.8600350242248238,1.959960883907085,1.423234227755616,1.0861738318844092,{"$f":"J37/$J$15","v":1.0781947416562145}]
[2,640,10.666666666666666,116.15978094145825,126.00221270772738,54.104591075673333,310.24596564642906,122.02949144425517,230.38019561139097,75.814229396522322,null,1.0729802389796659,1.397873575707717,1.1377094031301918,2.2662189000730382,1.1233468305855467,1.5134744655057382,0.75284109005585675]
[3,660,11,246.10418497326648,84.81493045791251,86.15320883664333,114.07515005988429,188.24564326570913,106.37337143316712,91.397524429935146,null,2.2732905061141064,0.94094022291191481,1.8116265894366788,0.83327195103319573,1.7329019750170158,0.69881606379665639,0.90758440028931375]
[4,680,11.333333333333334,109.72958539732548,79.049984307131083,61.137482826739294,136.96301213915822,162.78161572832889,117.79812570306605,79.445657960419283,null,1.0135838395055077,0.87698368027366758,1.285596798955684,1.0004583494710977,1.4984919624084956,0.77387057886155608,0.78890145313368243,null,null,"tau (ms)",null,null,"Ampl (pA)"]
[5,700,11.666666666666666,118.35193885142483,69.584233519957351,87.796251924643357,295.36424437882454,109.11034601467091,158.07291983776494,172.66993078292435,null,1.093229434519235,0.77197026332425867,1.8461764406378678,2.1575140602470171,1.0044191771106747,1.0384544002469094,1.7146256045233776,null,null,"Ctrl","TPA023B",null,"Ctrl","TPA023B"]
[6,720,12,90.961402851698338,null,62.697809281215278,370.71703240346631,266.13968198191924,219.98407587224011,88.567765104472855,null,0.8402201431399815,null,1.3184072877500128,2.7079351174196136,2.4499583232632487,1.4451775282460537,0.87948467399605301,null,"CELL1",108.259,150.0368,null,-89.293800000000005,-74.087450000000004]
[7,740,12.333333333333334,257.33305651477684,149.27614502537145,47.784660780476273,148.83703653241824,101.90398456359307,null,90.18812898768779,null,2.3770127856538195,{"$f":"E43/$E$15","v":1.6560755095508144},1.0048141352606603,1.0871932033599023,0.93808076005826768,null,0.89557501115092264,null,"CELL2",90.138490000000004,140.27459999999999,null,-93.543800000000005,-113.6874]
[8,760,12.666666666666666,152.48077373172455,165.39840268041519,43.540017251428999,171.59540117879831,79.409716844882922,125.53794290324052,null,null,1.4084811086285116,1.8349364793102365,0.91555792317362161,1.2534336764275147,0.73100897725321512,{"$f":"I44/$I$15","v":0.82471703147897446},null,null,"CELL3",47.555720000000001,87.352540000000005,null,-148.29390000000001,-110.6812]
[9,780,13,112.12855900857252,154.57065037770715,53.283307246828493,98.173425439041907,76.814375721678672,198.36072940825275,null,null,1.0357434136527681,1.7148129631988744,1.1204394761953653,0.71711640714264591,0.70711747208889464,{"$f":"I45/$I$15","v":1.3031237260727451},null,null,"CELL4",136.90029999999999,212.88069999999999,null,-110.6237,-97.593519999999998]
[10,800,13.333333333333334,234.43890340937085,119.25798680032939,67.59421600698964,58.146185333731665,157.23927320234606,123.9214421513667,null,null,2.1655370608273778,1.3230528643728843,1.4213687529918806,0.42473391683238187,1.4474717308489269,{"$f":"I46/$I$15","v":0.81409748753363165},null,null,"CELL5",108.63030000000001,162.28980000000001,null,-62.262549999999997,-88.393749999999997]
[11,820,13.666666666666666,122.63409179184856,133.98149168431803,null,142.8812077762187,142.78546679786368,235.44020592924491,null,null,1.1327841362251461,1.4863960150751023,null,1.0436883292037629,1.3144167010999133,{"$f":"I47/$I$15","v":1.5467160225369054},null,null,"CELL6",152.21940000000001,159.7148,null,-110.66549999999999,-116.6973]
[12,840,14,132.04864280624642,112.57612476349964,null,345.3972124477263,46.686263830579279,null,null,null,1.2197473442773878,1.2489240203066718,null,2.5229842691125715,0.42977206481204955,null,null,null,"CELL7",100.7042,115.6275,null,-114.1515,-110.8747]
[13,860,14.333333333333334,182.67042759262608,null,null,null,55.291090859389925,199.52923824663668,null,null,1.6873461491084758,null,null,null,0.50898410655826098,{"$f":"I49/$I$15","v":1.3108002031454316}]
[14,880,14.666666666666666,260.21649804126577,null,null,null,63.710082890605911,117.8408360484182,null,null,2.4036474414107483,null,null,null,0.58648543761405536,0.77415116294966246,null,null,"ttest",null,{"$f":"TTEST(U42:U48,V42:V48,2,1)","v":3.7155521203603957E-3},null,null,{"$f":"TTEST(X42:X48,Y42:Y48,2,1)","v":0.78259025343142663}]
[15,900,15,67.808531644808369,null,null,null,92.611087686245142,151.53108193204241,null,null,0.62635461172033902,null,null,null,0.85253466681001489,0.99547802981058253]
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[17,940,15.666666666666666,171.91579157539266,null,null,null,95.815646775120982,280.64507489198712,null,null,1.588004433495857,null,null,null,0.88203434965969085,1.8436877943946266]
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[{"$nulls":15},0,0]
[]
[]
[]
[]
[]
[null,null,null,"Ampl (pA)",{"$nulls":9},"% Variation of ampl values "]
[null,null,"time (min)","CELL1","CELL2","CELL3","CELL4","CELL5","CELL6","CELL7"]
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[3,60,1,-84.875,-82.9375,-91.6875,-162.79899999999998,-48.75,-160.69899999999998,-119.922,null,null,null,{"$f":"AVERAGE(D88:D97)","v":-74.087450000000004},-113.68744999999998,-110.68115,-97.593519999999998,-88.393749999999997,-116.6973,-110.87467000000001,"TPA023B"]
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[5,100,1.6666666666666667,-111,-68.0625,-141.875,-57.525799999999997,-42.3125,-136.28800000000001,-112.31400000000001,null,null,null,{"$f":"(N67-N65)/N65*100","v":-17.029569802158719},21.533923146162522,-25.363652854230672,-11.778808278553761,41.969370030620333,5.4504791466175133,-2.8705718813782957,"%change"]
[6,120,2,-103.375,-100.375,-134.93800000000002,-138.22899999999998,-55.0625,-128.00199999999998,-129.97399999999999]
[7,140,2.3333333333333335,-93.25,-85.4375,-209.81299999999999,-64.811299999999989,-49.4375,-94.182500000000005,-98.348300000000009]
[8,160,2.6666666666666665,-107.813,-150.875,-211.06299999999999,-88.0946,-60.5,-84.224599999999995,-98.805700000000002,null,null,null,{"$f":"AVERAGE(N69:T69)","v":1.7015956438684172},{"$f":"STDEV(N69:T69)/SQRT(7)","v":8.8840135137955212}]
[9,180,3,-75.1875,-89.125,-129.375,-78.306600000000003,-75.3125,-105.90300000000001,-144.31899999999999]
[10,200,3.3333333333333335,-84.9375,-94.9375,-98.9375,-79.039400000000001,-111.563,-68.155900000000003,-108.465]
[1,220,3.6666666666666665,-96.5625,-65.5625,-117.18799999999999,-70.278399999999991,-47.25,-99.208500000000001,-81.822199999999995]
[2,240,4,-54.3125,-80.625,-115.25,-68.992400000000004,-52.25,-75.974000000000004,-139.34]
[3,260,4.333333333333333,-93.8125,-125.125,-68.0625,-95.349299999999999,-49.6875,-125.21100000000001,-85.655500000000004]
[4,280,4.666666666666667,-49.625,-58.750000000000007,-162.06300000000002,-57.541800000000002,-49.8125,-140.33500000000001,-98.0822]
[5,300,5,-75.375,-70.875,-118.813,-56.591799999999999,-60.8125,-61.557600000000001,-102.24]
[6,320,5.333333333333333,-92.25,-98.125,-137.18799999999999,-119.63499999999999,-81.375,-133.405,-89.259]
[7,340,5.666666666666667,-87.75,-74.375,-87.625,-68.180800000000005,-63.875,-56.409699999999994,-97.023499999999999]
[8,360,6,-37.75,-104.125,-155.18799999999999,-91.415800000000004,-39,-80.383700000000005,-150.56500000000003]
[9,380,6.333333333333333,-120.687,-98.125,-153.56200000000001,-142.73000000000002,-58.250000000000007,-119.91499999999999,-135.95499999999998]
[10,400,6.666666666666667,-114.25,-66.4375,-124.812,-77.504999999999995,-69.9375,-107.035,-142.95000000000002]
[11,420,7,-88.125,-117.18799999999999,-120.938,-92.249700000000004,-60.75,-104.97500000000001,-96.955600000000004]
[12,440,7.333333333333333,-51.125,-127.37500000000001,null,-55.331299999999999,-42.25,-108.077,-144.56200000000001]
[13,460,7.666666666666667,-94.25,-105.188,-82.4375,-79.090199999999996,-52,-168.21099999999998,-130.79400000000001]
[14,480,8,-28.3125,-157.93700000000001,-84.875,-95.709599999999995,-89.75,-169.57,-90.601300000000009]
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[17,540,9,-60.875,-82.0625,-73.625,-65.6357,-96.875,-67.593399999999988,-95.727500000000006]
[18,560,9.3333333333333339,-88.125,-127.938,-110.687,-57.235199999999999,-76.75,-103.31699999999999,-69.140900000000002]
[19,580,9.6666666666666661,-55.375,-132.93700000000001,-123.625,-119.61599999999999,-60.312500000000007,-103.68700000000001,-147.58499999999998]
[20,600,10,-62.000000000000007,-126.37499999999999,-102.75,-129.71,-124.00000000000001,-127.08599999999998,-143.31100000000001]
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[2,640,10.666666666666666,-95.25,-141.875,-76.8125,-134.01399999999998,-67.375,-222.84299999999999,-85.557699999999997]
[3,660,{"$f":"B97/60","v":11},-102.062,-93,-128.06299999999999,-86.741799999999998,-88.0625,-81.331699999999998,-67.342300000000009]
[4,680,11.333333333333334,-120.12500000000001,-129.06200000000001,-92.625,-68.806100000000001,-109.75,-196.827,-104.303]
[5,700,11.666666666666666,-109,-134.68700000000001,-100.125,-89.5976,-88.125,-87.813099999999991,-111.114]
[6,720,12,-88.4375,-78.4375,-103.563,-52.985800000000005,-88.5,-121.01,-129.64700000000002]
[7,740,12.333333333333334,-63.75,-50.6875,-79.1875,-69.096400000000003,-89.25,-105.821]
[8,760,12.666666666666666,-122.187,-44.4375,-95.5625,-65.170200000000008,-107.25,-128.239]
[9,780,13,-104.812,-93.5625,-59.875,-65.131900000000002,-77.6875,-151.541]
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[19,980,16.333333333333332,-92.625,null,null,null,-102.625,-166.84399999999999]
[20,1000,16.666666666666668,-94.8125,null,null,null,-78,-139.07299999999998]
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[{"$nulls":8},-186.369]
[{"$nulls":8},-146.405]
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