authors: - firstname: Encarnacion lastname: Torres affiliation: 'Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain ' id: 'ORCID:0000-0001-9077-6504' - firstname: Giulliana lastname: Pellegrino affiliation: 'Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France' - firstname: Melissa lastname: Granados-Rodriguez affiliation: 'Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain ' - firstname: 'Antonio Carlos' lastname: Fuentes-Fayos affiliation: 'Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain ' - firstname: Inmaculada lastname: Velasco affiliation: 'Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain ' - firstname: Adrián lastname: Coutteau-Robles affiliation: 'Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France' - firstname: Amandine lastname: Legrand affiliation: 'Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France' - firstname: Marya lastname: Shanabrough affiliation: "Program in Integrative Cell Signaling and\nNeurobiology of Metabolism, Department of Comparative Medicine, Yale University\nSchool of Medicine, New Haven, CT, USA" - firstname: Cecilia lastname: Perdices-Lopez affiliation: 'Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain ' - firstname: Silvia lastname: Leon affiliation: 'Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain ' - firstname: 'Shel H' lastname: Yeo affiliation: 'Reproductive Physiology Group, Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK' - firstname: Stephen lastname: Manchishi affiliation: 'Reproductive Physiology Group, Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK' - firstname: 'María Jesús' lastname: Sanchez-Tapia affiliation: 'Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain ' - firstname: 'Victor Manuel' lastname: Navarro affiliation: 'Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women''s Hospital, Harvard Medical School, Boston, USA' - firstname: Rafael lastname: Pineda affiliation: 'Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain ' - firstname: Juan lastname: Roa affiliation: 'Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain' - firstname: Fred lastname: Naftolin affiliation: 'Centro de Fecundacion In Vitro Angela Palumbo (FIVAP), La Laguna, Spain' - firstname: Jesús lastname: Argente affiliation: 'CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain; Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, and IMDEA Food Institute, CEI UAM + CSIC MAdrid, Madrid, Spain; Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain ' - firstname: 'Raúl M.' lastname: Luque affiliation: 'Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain' - firstname: Julie lastname: Chowen affiliation: "CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud \nCarlos III, Madrid, Spain; Department of Endocrinology, Hospital \nInfantil Universitario Niño Jesús, Instituto de Investigación La \nPrincesa, and IMDEA Food Institute, CEI UAM + CSIC MAdrid, Madrid, Spain" - firstname: 'Tamas L.' lastname: Horvath affiliation: "Program in Integrative Cell Signaling and\nNeurobiology of Metabolism, Department of Comparative Medicine, Yale University\nSchool of Medicine, New Haven, CT, USA" - firstname: Vicent lastname: Prevot affiliation: 'Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France' - firstname: Ariane lastname: Sharif affiliation: 'Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S1172, Lille, France' - firstname: 'William H.' lastname: Colledge affiliation: 'Reproductive Physiology Group, Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK' - firstname: Manuel lastname: Tena-Sempere affiliation: 'Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain' - firstname: Antonio lastname: Romero affiliation: 'Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain ' title: 'Kisspeptin signaling in astrocytes centrally modulates the reproductive axis' description: 'Reproduction is safeguarded by multiple, often cooperative regulatory networks. Kisspeptin signaling, via Kiss1r, plays a fundamental role in reproductive control, primarily by regulation of hypothalamic GnRH neurons. We disclose herein a pathway for direct kisspeptin actions in astrocytes that contribute to central reproductive modulation. ' keywords: - Kisspeptin-signaling - Astrocytes - Reproduction references: - id: 'doi::tba' reftype: IsSupplementTo citation: 'E. Torres, G. Pellegrino, I. Velasco, A.C. Fuentes-Fayos, M. Granados-Rodríguez, A. Coutteau-Robles, A. Legrand, M. Shanabrough, C. Perdices-Lopez, S. Leon, S.H. Yeo, S.M. Manchishi, M.J. Sánchez-Tapia, R. Pineda, J. Roa, F. Naftolin, J. Argente, R.M. Luque, V. Prevot, J. Chowen, T.L. Horvath, A. Sharif, W.H. Colledge, M. Tena-Sempere, A. Romero-Ruiz: Kisspeptin signaling in astrocytes centrally modulates the reproductive axis' license: name: 'Creative Commons CC0 1.0 Public Domain Dedication' url: 'https://creativecommons.org/publicdomain/zero/1.0/' funding: - 'Agencia Estatal de Investigación, Spain, co-funded with EU funds from FEDER Program; BFY2017-83934-P ' - 'Agencia Estatal de Investigación, Spain, co-funded with EU funds from FEDER Program; PID2019-105564RB-I00 ' - 'Agencia Estatal de Investigación, Spain, co-funded with EU funds from FEDER Program; PID2020-118660GB-I00 ' - 'Flexi-Met, Instituto de Salud Carlos III, Ministerio de Sanidad, Spain; Project PIE-14-00005' - 'Junta de Andalucía, Spain; Projects P12-FQM-01943 and P18-RT-4093 ' - 'Universidad de Córdoba-FEDER; Project 1254821 ' - 'BBSRC Project Grant; BB/K003178/1' resourcetype: Dataset templateversion: 1.2