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Calcium responses of perirhinal axons in layer 1 of S1 to microstimulation before and after the first training session. Pooled trials from all animals (n=3). 5-sec recording at 30 Hz, and stimulation occurred at 2 seconds.
Entry | Description |
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prePSTCa |
Baseline-subtracted ∆F/F responses before the training |
postPSTCa |
Baseline-subtracted ∆F/F responses after the training |
rewardPSTCa |
Baseline-subtracted ∆F/F responses to reward alone |
Excitatory postsynaptic currents (EPSCs) of S1 neurons in response to optogenetic activation of perirhinal axons in layer 1 of S1. See Fig. S4 for individual cell responses.
Entry | Description |
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preCNO |
EPSCs before CNO application |
postCNO |
EPSCs after CNO application |
Distribution of PRh projection in S1. Normalized signal distribution was measured along the neocortical depths.
For each file, the entry *Depth
represents the binned absolute depths of the neocortex. The entry norm_*
contains the normalized signals in the bins, where each column corresponds to the data from a brain section.
File name | Description |
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ChicagoBlue.mat | Intensity of ChicagoBlue in S1 after injection in mouse S1. |
MouseYFP.mat | Intensity of YFP (axon terminals) after injection of rAAV was in mouse PRh. |
RatYFP.mat | Intensity of YFP (axon terminals) after injection of rAAV was in rat PRh. |
Effects of DREADD inhibition of PRh inputs to L1 of S1 on learning of the microstimulation detection task.
Condition | Description |
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Untrained | Animals without any prior experience of pairing. No virus was expressed. No drug injection was performed. |
Ctrl | Animals after pairing sessions. No virus expression, but CNO was injected into L1 of S1. |
Dreadd | Animals after pairing sessions. Virus was expressed in PRh, and CNO was injected into L1 of S1 before testing of the learning. |
Expert_preCNO | Animals being fully trained with the task. Virus was expressed in PRh. Data was obtained before injection of CNO into L1 of S1. |
Expert_postCNO | Animals being fully trained with the task. Virus was expressed in PRh. Data was obtained after injection of CNO into L1 of S1. |
Entry | Description |
---|---|
<cond>_cumvals |
The cumulative learning curve statistics for the condition. Values on row N (N=1, ... 100) represents the cumulative learning score of each animal after N trials. |
<cond> |
The normalized learning scores for each animal belonging to the condition. |
datacite.yml | |
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Title | Perirhinal input to neocortical layer 1 controls learning |
Authors |
Doron,Guy;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0003-1252-5747
Shin,Jiyun N.;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0002-0534-6938 Takahashi,Naoya;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0002-6008-4627 Drüke,Moritz;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0002-6787-9377 Bocklisch,Christina;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: Skenderi,Salina;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0003-4779-4541 de Mont,Lisa;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0003-3829-0712 Toumazou,Maria;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: Ledderose,Julia;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0001-5458-6287 Brecht,Michael;Institut für Biologie, House 6, Philippstr. 13, Humboldt Universität, Berlin, 10115 Germany.;ORCID: 0000-0002-5387-0953 Naud,Richard;uOttawa Brain and Mind Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada.;ORCID: 0000-0001-7383-3095 Larkum,Matthew E.;Institut für Biologie, Neurocure Center for Excellence, Chariteplatz 1 / Virchowweg 6, Charité Universitätsmedizin Berlin & Humboldt Universität, Berlin, 10117 Germany.;ORCID: 0000-0001-9799-2656 |
Description | Example description that can contain linebreaks but has to maintain indentation. |
License | Creative Commons CC0 1.0 Public Domain Dedication (https://creativecommons.org/publicdomain/zero/1.0/) |
References |
PublicationName1 [doi:10.xxx/zzzz] (IsSupplementTo)
PublicationName2 [arxiv:mmmm.nnnn] (IsSupplementTo) PublicationName3 [pmid:nnnnnnnn] (IsReferencedBy) |
Funding |
DFG, EXC 257 NeuroCure
DFG, DFG.327654276 (SFB 1315) EU, EU.785907 (HBP SGA2) EU, EU.670118 (Active Cortex) NSERC, Discovery grant CIHR, Project grant |
Keywords |
Neuroscience
Electrophysiology Behavior Learning and memory Neocortex Dendrites L5 pyramidal neuron Perirhinal cortex Layer 1 |
Resource Type |
Dataset |