# Metadata for DOI registration according to DataCite Metadata Schema 4.1.
# For detailed schema description see https://doi.org/10.5438/0014

## Required fields

# The main researchers involved. Include digital identifier (e.g., ORCID)
# if possible, including the prefix to indicate its type.
authors:
  -
    firstname: "Fikret Emre"
    lastname: "Kapucu"
    affiliation: "Neuro Group, Faculty of Medicine and Health Technology, Tampere University"
    id: "ORCID:0000-0002-4557-6885"
  -
    firstname: "Andrey"
    lastname: "Vinogradov"
    affiliation: "Neuro Group, Faculty of Medicine and Health Technology, Tampere University"
    id: "ORCID:0000-0003-1894-773X"
  -
    firstname: "Tanja"
    lastname: "Hyvärinen"
    affiliation: "Neuro Group, Faculty of Medicine and Health Technology, Tampere University"
    id: "ORCID:0000-0002-8723-8817"
  -
    firstname: "Laura"
    lastname: "Ylä-Outinen"
    affiliation: "Neuro Group, Faculty of Medicine and Health Technology, Tampere University"
    id: "ORCID:0000-0001-7817-9395"
  -
    firstname: "Susanna"
    lastname: "Narkilahti"
    affiliation: "Neuro Group, Faculty of Medicine and Health Technology, Tampere University"
    id: "ORCID:0000-0002-7602-4418"
    

# A title to describe the published resource.
title: "Comparative microelectrode array dataset of the functional development of hPSC-derived and rat neuronal networks "

# Additional information about the resource, e.g., a brief abstract.
description: |
  We provide a dataset of microelectrode array recordings (MEA) from human pluripotent stem cell (hPSC)-derived and 
  rat embryonic cortical neurons during in vitro maturation and pharmacological treatment at their mature stage. 
  Together with the recorded raw MEA data, we share the analysis code that produces the key scientific findings
  published previously with this dataset (Hyvärinen et al., 2019), including PCA analysis to reveal the distinction
  between rat and human cell activity features. The data enables evaluation and comparison of hPSC-derived and rat 
  cortical cultures in terms of functional development and response to pharmacological treatment. The 12500 Hz 
  sampled data is recorded with Axion 12-well plates (for developmental tracking) and 48-well plates (for 
  pharmacological experiments). Raw data constitute time series of extracellularly recorded voltage values in Volts.
  The duration of the recordings varies from 10 to 30 minutes depending on the experimental set-up. Each raw MEA data
  file contains organised meta-data. This dataset is valuable for experimental and computational neuroscientists and
  any signal analyst with interest for neuronal signalling. The accurate detailed description of data is delivered in
  the corresponding publication (Kapucu et al., submitted).

# Lit of keywords the resource should be associated with.
# Give as many keywords as possible, to make the resource findable.
keywords:
  - Neuroscience
  - Electrophysiology
  - Microelectrode array
  - MEA
  - Extracellular recordings
  - Action potential
  - Neuronal connectivity
  - Spike analysis
  - Burst analysis
  - Stem cell-derived neurons
  - Neuronal network development

# License information for this resource. Please provide the license name and/or a link to the license.
# Please add also a corresponding LICENSE file to the repository.
license:
  name: "Creative Commons Attribution 4.0 International License"
  url: "https://creativecommons.org/licenses/by/4.0/"



## Optional Fields

# Funding information for this resource.
# Separate funder name and grant number by comma.
funding:
  - "Academy of Finland, 332693 (Fikret Emre Kapucu), 286990/326436 (Laura Ylä-Outinen), 312414 and 311017 (Susanna Narkilahti)"
  - "Orion Research Foundation, grant for postdoctoral research 2019 (Fikret Emre Kapucu), grant for doctoral dissertation work 2020 (Andrey Vinogradov)"


# Related publications. reftype might be: IsSupplementTo, IsDescribedBy, IsReferencedBy.
# Please provide digital identifier (e.g., DOI) if possible.
# Add a prefix to the ID, separated by a colon, to indicate the source.
# Supported sources are: DOI, arXiv, PMID
# In the citation field, please provide the full reference, including title, authors, journal etc.
references:
  -
    id: "doi:10.xxx/zzzz"
    reftype: "IsDescribedBy"
    citation: "Kapucu, F.E., Vinogradov A., Hyvärinen T., Ylä-Outinen L., Narkilahti S. (2021, submitted). Comparative microelectrode array dataset of functional development of human PSC-derived and rat neuronal networks"
  -
    id: "doi:10.1038/s41598-019-53647-8"
    reftype: "IsSupplementTo"
    citation: "Hyvärinen, T., Hyysalo, A., Kapucu, F.E., Aarnos, L., Vinogradov, A., Eglen, J.E., Ylä-Outinen, L., Narkilahti, S. (2019). Functional characterization of human pluripotent stem cell-derived cortical networks differentiated on laminin-521 substrate: comparison to rat cortical cultures. Scientific Reports volume 9, 17125."


# Resource type. Default is Dataset, other possible values are Software, DataPaper, Image, Text.
resourcetype: Dataset

# Do not edit or remove the following line
templateversion: 1.2