# Metadata for DOI registration according to DataCite Metadata Schema 4.1.
# For detailed schema description see https://doi.org/10.5438/0014

## Required fields

# The main researchers involved. Include digital identifier (e.g., ORCID)
# if possible, including the prefix to indicate its type.
authors:
  -
    firstname: "Lu"
    lastname: "Zhang"
    affiliation: "Neuroscience Paris-Seine – Institut de biologie Paris-Seine, Sorbonne Université, INSERM, CNRS, Paris, France"
  -
    firstname: "Julien"
    lastname: "Fournier"
    affiliation: "Neuroscience Paris-Seine – Institut de biologie Paris-Seine, Sorbonne Université, INSERM, CNRS, Paris, France"
    id: "ORCID: 0000-0001-7167-8132"
  -
    firstname: "Mehdi"
    lastname: "Fallahnezhad"
    affiliation: "Neuroscience Paris-Seine – Institut de biologie Paris-Seine, Sorbonne Université, INSERM, CNRS, Paris, France"
    id: "ORCID: 0000-0002-7968-1771"
  -
    firstname: "Anne-Lise"
    lastname: "Paradis"
    affiliation: "Neuroscience Paris-Seine – Institut de biologie Paris-Seine, Sorbonne Université, INSERM, CNRS, Paris, France"
    id: "ORCID: 0000-0002-5933-0448"
  -
    firstname: "Christelle"
    lastname: "Rochefort"
    affiliation: "Neuroscience Paris-Seine – Institut de biologie Paris-Seine, Sorbonne Université, INSERM, CNRS, Paris, France"
    id: "ORCID: 0000-0001-8466-5218"
  -
    firstname: "Laure"
    lastname: "Rondi-Reig"
    affiliation: "Neuroscience Paris-Seine – Institut de biologie Paris-Seine, Sorbonne Université, INSERM, CNRS, Paris, France"
    id: "ORCID: 0000-0003-1006-0501"

# A title to describe the published resource.
title: "The cerebellum promotes sequential foraging strategies and contributes to the directional modulation of hippocampal place cells"

# Additional information about the resource, e.g., a brief abstract.
description: |
  The cerebellum contributes to spatial coding in the hippocampus. 
  When PKC-dependent mechanisms are impaired in cerebellar Purkinje cells, 
  hippocampal place cells indeed lose their spatial selectivity in the dark, 
  when the animal relies mostly on self-motion cues to navigate. 
  This impairment in PKC-dependent cerebellar functions additionally 
  leads to behavioral deficits in using both external and self-motion 
  cues when learning a goal-oriented navigation task. However, it is 
  unclear how cerebellum influences the exploration strategy used by 
  an animal during free foraging in an open environment. 
  Here we recorded hippocampal place cells in mice with impaired PKC-dependent 
  mechanisms (L7-PKCI) and in their littermate controls while they performed a 
  foraging task where they were rewarded for visiting a subset of 
  hidden locations. We found that L7-PKCI and control mice developed different 
  foraging strategies: while control mice repeated reliable spatial sequences 
  to maximize their rewards, L7-PKCI mice persisted to use a random foraging 
  strategy. The sequence-based strategy was associated with more place cells 
  exhibiting theta-phase precession and theta modulation. It was also correlated
  with a larger fraction of place cells that were modulated concomitantly by 
  movement direction and speed. Finally, in the dark, the modulation of place 
  cells by movement direction was markedly reduced in L7-PKCI mice, demonstrating 
  that PKC-dependent cerebellar functions control how self-motion cues influence 
  not only position but also direction coding in the hippocampus. Thus, the cerebellum 
  contributes to the development of optimal sequential paths during foraging, 
  possibly by controlling how self-motion and theta signals contribute to place cells coding.
  
  This data set includes behavioral tracking data corresponding to several 
  navigational variables such as position, movement direction, speed and 
  reward delivery. For sessions where behavior was combined with hippocampal 
  recordings, it also includes spike times from hippocampal single units and 
  LFP oscillations.

# Lit of keywords the resource should be associated with.
# Give as many keywords as possible, to make the resource findable.
keywords:
  - Neuroscience
  - Navigation
  - Cerebellum
  - Hippocampus
  - Place cells
  - Theta phase precession

# License information for this resource. Please provide the license name and/or a link to the license.
# Please add also a corresponding LICENSE file to the repository.
license:
  name: "Creative Commons Attribution 4.0 International License"
  url: "https://creativecommons.org/licenses/by/4.0/"



## Optional Fields

# Funding information for this resource.
# Separate funder name and grant number by comma.
funding:
  - "Fondation pour la Recherche Médicale, DEQ20160334907-France"
  - "National Agency for Research, ANR-17-CE37-0015-01 and ANR-18-CE16-0010-02"
  - "Human Frontier Science program CDA 00058 -2019"
  - "Institut Universitaire de France"
  - "CNRS"
  - "INSERM"
  - "Sorbonne Universites"


# Related publications. reftype might be: IsSupplementTo, IsDescribedBy, IsReferencedBy.
# Please provide digital identifier (e.g., DOI) if possible.
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references:
  -
    id: "doi:tba"
    reftype: "IsSupplementTo"
    citation: "Lu Zhang*, Julien Fournier*, Mehdi Fallahnezhad, Anne-Lise Paradis, Christelle Rochefort, Laure Rondi-Reig (2023). The cerebellum promotes sequential foraging strategies and contributes to the directional modulation of hippocampal place cells, iScience."

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resourcetype: Dataset

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templateversion: 1.2