# Metadata for DOI registration according to DataCite Metadata Schema 4.1.
# For detailed schema description see https://doi.org/10.5438/0014

## Required fields

# The main researchers involved. Include digital identifier (e.g., ORCID)
# if possible, including the prefix to indicate its type.
authors:
  -
    firstname: "Susana Andrea"
    lastname: "Contreras Ceballos"
    affiliation: "Institute for Theoretical Biology, Humboldt-University of Berlin; Bernstein Center for Computational Neuroscience Berlin"
    id: "ORCID:0000-0002-1819-0899"
  -
    firstname: "Jan-Hendrik"
    lastname: "Schleimer"
    affiliation: "Institute for Theoretical Biology, Humboldt-University of Berlin; Bernstein Center for Computational Neuroscience Berlin"
    id: "ORCID:0000-0002-2156-330X"
  -
    firstname: "Allan T"
    lastname: "Gulledge"
    affiliation: "Molecular and Systems Biology, Geisel School of Medicine at Dartmouth College"
    id: "ORCID:0000-0002-5721-374X"
  -
    firstname: "Susanne"
    lastname: "Schreiber"
    affiliation: "Institute for Theoretical Biology, Humboldt-University of Berlin; Bernstein Center for Computational Neuroscience Berlin"
    id: "ORCID:0000-0003-3913-5650"


# A title to describe the published resource.
title: 'Recordings shown in "Activity-mediated accumulation of potassium induces a switch in firing pattern and neuronal excitability type "'

# Additional information about the resource, e.g., a brief abstract.
description: |
  During normal neuronal activity, ionic concentration gradients across a neuron’s membrane are often assumed to be stable. Prolonged spiking activity, however, can reduce transmembrane gradients and affect voltage dynamics. Based on mathematical modeling, we here investigate the impact of neuronal activity on ionic concentrations and, consequently, the dynamics of action potential generation. We find that intense spiking activity on the order of a second suffices to induce changes in ionic reversal potentials and to consistently induce a switch from a regular to an intermittent firing mode. This transition is caused by a qualitative alteration in the system’s voltage dynamics, mathematically corresponding to a co-dimension-two bifurcation from a saddle-node on invariant cycle (SNIC) to a homoclinic orbit bifurcation (HOM). Our electrophysiological recordings in mouse cortical pyramidal neurons confirm the changes in action potential dynamics predicted by the models: (i) activity-dependent increases in intracellular sodium concentration directly reduce action potential amplitudes, an effect that previously had been attributed soley to sodium channel inactivation; (ii) extracellular potassium accumulation switches action potential generation from tonic firing to intermittently interrupted output. Individual neurons thus may respond very differently to the same input stimuli, depending on their recent patterns of activity or the current brain-state.



# Lit of keywords the resource should be associated with.
# Give as many keywords as possible, to make the resource findable.
keywords:
  - conductance-based modelling
  - onset bifurcation
  - adaptation
  - extracellular space
  - extracellular potassium concentration
  - spiking irregularity
  - spike amplitude reduction
  - sodium accumulation
  - slow-fast analysis
  - bistability

# License information for this resource. Please provide the license name and/or a link to the license.
# Please add also a corresponding LICENSE file to the repository.
license:
  name: "Creative Commons CC0 1.0 Public Domain Dedication"
  url: "https://creativecommons.org/publicdomain/zero/1.0/"



## Optional Fields

# Funding information for this resource.
# Separate funder name and grant number by comma.
funding:
  - "BMBF, BMBF.01GQ1403"
  - " ERC, ERC.864243"
  - "R01, MH099054"
  - "GRK, 1589/2"

# Related publications. reftype might be: IsSupplementTo, IsDescribedBy, IsReferencedBy.
# Please provide digital identifier (e.g., DOI) if possible.
# Add a prefix to the ID, separated by a colon, to indicate the source.
# Supported sources are: DOI, arXiv, PMID
# In the citation field, please provide the full reference, including title, authors, journal etc.
references:
  -
    id: "doi:10.1101/2020.11.30.403782"
    reftype: "IsSupplementTo"
    citation: "Activity-mediated accumulation of potassium induces a switch in firing pattern and neuronal excitability type"



# Resource type. Default is Dataset, other possible values are Software, Image, Text.
resourcetype: Dataset

# Do not edit or remove the following line
templateversion: 1.2