Activity-mediated accumulation of potassium induces a switch in firing pattern and neuronal excitability type

Susana Contreras 178ae923f8 Subir archivos a 'functions' 7 months ago
Data fd9f84b0ef Added extracellular potassium dependent irregularity recordings 7 months ago
cfg e6a0adce33 added cfg folder 7 months ago
functions 178ae923f8 Subir archivos a 'functions' 7 months ago
LICENSE 04fb0ae324 Initial commit 7 months ago
README.md dfa948d16b Update 'README.md' 7 months ago
datacite.yml d51365d4d8 updated datacite 7 months ago
p_graphs_Ko_dependent_Irregularity.ipynb 1e1cd09b96 Subir archivos a '' 7 months ago
p_graphs_spkAmplDecay_time_scales.ipynb 0b115b4208 notebook spike amplitude 7 months ago

README.md

Activity-mediated accumulation of potassium induces a switch in firing pattern and neuronal excitability type

datacite.yml
Title Recordings shown in "Activity-mediated accumulation of potassium induces a switch in firing pattern and neuronal excitability type "
Authors Contreras Ceballos,Susana Andrea;Institute for Theoretical Biology, Humboldt-University of Berlin; Bernstein Center for Computational Neuroscience Berlin;ORCID:0000-0002-1819-0899
Schleimer,Jan-Hendrik;Institute for Theoretical Biology, Humboldt-University of Berlin; Bernstein Center for Computational Neuroscience Berlin;ORCID:0000-0002-2156-330X
Gulledge,Allan T;Molecular and Systems Biology, Geisel School of Medicine at Dartmouth College;ORCID:0000-0002-5721-374X
Schreiber,Susanne;Institute for Theoretical Biology, Humboldt-University of Berlin; Bernstein Center for Computational Neuroscience Berlin;ORCID:0000-0003-3913-5650
Description During normal neuronal activity, ionic concentration gradients across a neuron’s membrane are often assumed to be stable. Prolonged spiking activity, however, can reduce transmembrane gradients and affect voltage dynamics. Based on mathematical modeling, we here investigate the impact of neuronal activity on ionic concentrations and, consequently, the dynamics of action potential generation. We find that intense spiking activity on the order of a second suffices to induce changes in ionic reversal potentials and to consistently induce a switch from a regular to an intermittent firing mode. This transition is caused by a qualitative alteration in the system’s voltage dynamics, mathematically corresponding to a co-dimension-two bifurcation from a saddle-node on invariant cycle (SNIC) to a homoclinic orbit bifurcation (HOM). Our electrophysiological recordings in mouse cortical pyramidal neurons confirm the changes in action potential dynamics predicted by the models: (i) activity-dependent increases in intracellular sodium concentration directly reduce action potential amplitudes, an effect that previously had been attributed soley to sodium channel inactivation; (ii) extracellular potassium accumulation switches action potential generation from tonic firing to intermittently interrupted output. Individual neurons thus may respond very differently to the same input stimuli, depending on their recent patterns of activity or the current brain-state.
License Creative Commons CC0 1.0 Public Domain Dedication (https://creativecommons.org/publicdomain/zero/1.0/)
References Activity-mediated accumulation of potassium induces a switch in firing pattern and neuronal excitability type [doi:10.1101/2020.11.30.403782] (IsSupplementTo)
Funding BMBF, BMBF.01GQ1403
ERC, ERC.864243
R01, MH099054
GRK, 1589/2
Keywords conductance-based modelling
onset bifurcation
adaptation
extracellular space
extracellular potassium concentration
spiking irregularity
spike amplitude reduction
sodium accumulation
slow-fast analysis
bistability
Resource Type Dataset