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- <neuroml xmlns="http://www.neuroml.org/schema/neuroml2" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.neuroml.org/schema/neuroml2 https://raw.github.com/NeuroML/NeuroML2/development/Schemas/NeuroML2/NeuroML_v2.3.1.xsd" id="NeuroML2_file_exported_from_NEURON">
- <notes> NeuroML 2 file generated from ModelView by: NEURON -- VERSION 8.2.2 release/8.2 (93d41fafd) 2022-12-15
- Authors: Michael Hines, Sushil Kambampati and Padraig Gleeson,
- Yale University and UCL
- </notes>
- <include href="CaDynamics_E2_NML2.nml"/>
- <include href="channels/pas.channel.nml"/>
- <include href="channels/Ih.channel.nml"/>
- <include href="channels/NaTg/NaTg.channel.nml"/>
- <include href="channels/Nap.channel.nml"/>
- <include href="channels/K_P.channel.nml"/>
- <include href="channels/K_T.channel.nml"/>
- <include href="channels/Kv3_1.channel.nml"/>
- <include href="channels/Im.channel.nml"/>
- <include href="channels/SK.channel.nml"/>
- <include href="channels/Ca_HVA.channel.nml"/>
- <include href="channels/Ca_LVA.channel.nml"/>
- <cell id="HL23VIP">
- <notes>Cell: HL23VIP exported from NEURON ModelView. Reference: Yao, H. K.; Guet-McCreight, A.; Mazza, F.; Moradi Chameh, H.; Prevot, T. D.; Griffiths, J. D.; Tripathy, S. J.; Valiante, T. A.; Sibille, E. & Hay, E. Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits Cell Reports, Elsevier, 2022, 38</notes>
- <morphology id="morphology">
- <segment id="0" name="Seg0_soma_0">
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- <distal x="313.638" y="263.232" z="28.84" diameter="16.9312"/>
- </segment>
- <segment id="2" name="Seg1_soma_0">
- <parent segment="0"/>
- <distal x="322.104" y="263.232" z="28.84" diameter="16.9312"/>
- </segment>
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- <distal x="313.7" y="254.871" z="31.423" diameter="0.7032"/>
- </segment>
- <segment id="2652" name="Seg1_dend_46">
- <parent segment="2651"/>
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- </segment>
- <segment id="2653" name="Seg2_dend_46">
- <parent segment="2652"/>
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- </segment>
- <segment id="2654" name="Seg3_dend_46">
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- <distal x="314.169" y="251.52" z="30.9742" diameter="0.7308"/>
- </segment>
- <segment id="2655" name="Seg4_dend_46">
- <parent segment="2654"/>
- <distal x="314.077" y="250.391" z="30.7966" diameter="0.7072"/>
- </segment>
- <segment id="2656" name="Seg5_dend_46">
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- </segment>
- <segment id="2657" name="Seg6_dend_46">
- <parent segment="2656"/>
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- <segment id="2658" name="Seg7_dend_46">
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- </segment>
- <segment id="2659" name="Seg8_dend_46">
- <parent segment="2658"/>
- <distal x="313.453" y="245.899" z="30.6387" diameter="0.92"/>
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- <segment id="2660" name="Seg9_dend_46">
- <parent segment="2659"/>
- <distal x="313.059" y="244.83" z="30.644" diameter="0.9666"/>
- </segment>
- <segment id="2661" name="Seg10_dend_46">
- <parent segment="2660"/>
- <distal x="313.418" y="243.749" z="30.6074" diameter="1.0328"/>
- </segment>
- <segment id="2662" name="Seg11_dend_46">
- <parent segment="2661"/>
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- <member segment="1088"/>
- <member segment="1089"/>
- <member segment="1090"/>
- <member segment="1091"/>
- <member segment="1092"/>
- <member segment="1093"/>
- <member segment="1094"/>
- <member segment="1095"/>
- <member segment="1096"/>
- <member segment="1097"/>
- <member segment="1098"/>
- <member segment="1099"/>
- <member segment="1100"/>
- <member segment="1101"/>
- <member segment="1102"/>
- <member segment="1103"/>
- <member segment="1104"/>
- <member segment="1105"/>
- <member segment="1106"/>
- <member segment="1107"/>
- <member segment="1108"/>
- <member segment="1109"/>
- <member segment="1110"/>
- <member segment="1111"/>
- <member segment="1112"/>
- <member segment="1113"/>
- <member segment="1114"/>
- <member segment="1115"/>
- <member segment="1116"/>
- <member segment="1117"/>
- <member segment="1118"/>
- <member segment="1119"/>
- <member segment="1120"/>
- <member segment="1121"/>
- <member segment="1122"/>
- <member segment="1123"/>
- <member segment="1124"/>
- <member segment="1125"/>
- <member segment="1126"/>
- <member segment="1127"/>
- <member segment="1128"/>
- <member segment="1129"/>
- <member segment="1130"/>
- <member segment="1131"/>
- <member segment="1132"/>
- <member segment="1133"/>
- <member segment="1134"/>
- <member segment="1135"/>
- <member segment="1136"/>
- <member segment="1137"/>
- <member segment="1138"/>
- <member segment="1139"/>
- <member segment="1140"/>
- <member segment="1141"/>
- <member segment="1142"/>
- <member segment="1143"/>
- <member segment="1144"/>
- <member segment="1145"/>
- <member segment="1146"/>
- <member segment="1147"/>
- <member segment="1148"/>
- <member segment="1149"/>
- <member segment="1150"/>
- <member segment="1151"/>
- <member segment="1152"/>
- <member segment="1153"/>
- <member segment="1154"/>
- <member segment="1155"/>
- <member segment="1156"/>
- <member segment="1157"/>
- <member segment="1158"/>
- <member segment="1159"/>
- <member segment="1160"/>
- <member segment="1161"/>
- <member segment="1162"/>
- <member segment="1163"/>
- <member segment="1164"/>
- <member segment="1165"/>
- <member segment="1166"/>
- <member segment="1167"/>
- <member segment="1168"/>
- <member segment="1169"/>
- <member segment="1170"/>
- <member segment="1171"/>
- <member segment="1172"/>
- <member segment="1173"/>
- <member segment="1174"/>
- <member segment="1175"/>
- <member segment="1176"/>
- <member segment="1177"/>
- <member segment="1178"/>
- <member segment="1179"/>
- <member segment="1180"/>
- <member segment="1181"/>
- <member segment="1182"/>
- <member segment="1183"/>
- <member segment="1184"/>
- </segmentGroup>
- <segmentGroup id="soma_group" neuroLexId="GO:0043025">
- <notes>Default soma segment group for the cell</notes>
- <include segmentGroup="soma_0"/>
- </segmentGroup>
- <segmentGroup id="axon_group" neuroLexId="GO:0030424">
- <notes>Default axon segment group for the cell</notes>
- <include segmentGroup="axon_0"/>
- <include segmentGroup="axon_1"/>
- </segmentGroup>
- <segmentGroup id="dendrite_group" neuroLexId="GO:0030425">
- <notes>Default dendrite segment group for the cell</notes>
- <include segmentGroup="dend_0"/>
- <include segmentGroup="dend_1"/>
- <include segmentGroup="dend_2"/>
- <include segmentGroup="dend_3"/>
- <include segmentGroup="dend_4"/>
- <include segmentGroup="dend_5"/>
- <include segmentGroup="dend_6"/>
- <include segmentGroup="dend_7"/>
- <include segmentGroup="dend_8"/>
- <include segmentGroup="dend_9"/>
- <include segmentGroup="dend_10"/>
- <include segmentGroup="dend_11"/>
- <include segmentGroup="dend_12"/>
- <include segmentGroup="dend_13"/>
- <include segmentGroup="dend_14"/>
- <include segmentGroup="dend_15"/>
- <include segmentGroup="dend_16"/>
- <include segmentGroup="dend_17"/>
- <include segmentGroup="dend_18"/>
- <include segmentGroup="dend_19"/>
- <include segmentGroup="dend_20"/>
- <include segmentGroup="dend_21"/>
- <include segmentGroup="dend_22"/>
- <include segmentGroup="dend_23"/>
- <include segmentGroup="dend_24"/>
- <include segmentGroup="dend_25"/>
- <include segmentGroup="dend_26"/>
- <include segmentGroup="dend_27"/>
- <include segmentGroup="dend_28"/>
- <include segmentGroup="dend_29"/>
- <include segmentGroup="dend_30"/>
- <include segmentGroup="dend_31"/>
- <include segmentGroup="dend_32"/>
- <include segmentGroup="dend_33"/>
- <include segmentGroup="dend_34"/>
- <include segmentGroup="dend_35"/>
- <include segmentGroup="dend_36"/>
- <include segmentGroup="dend_37"/>
- <include segmentGroup="dend_38"/>
- <include segmentGroup="dend_39"/>
- <include segmentGroup="dend_40"/>
- <include segmentGroup="dend_41"/>
- <include segmentGroup="dend_42"/>
- <include segmentGroup="dend_43"/>
- <include segmentGroup="dend_44"/>
- <include segmentGroup="dend_45"/>
- <include segmentGroup="dend_46"/>
- <include segmentGroup="dend_47"/>
- <include segmentGroup="dend_48"/>
- <include segmentGroup="dend_49"/>
- <include segmentGroup="dend_50"/>
- <include segmentGroup="dend_51"/>
- <include segmentGroup="dend_52"/>
- </segmentGroup>
- <segmentGroup id="all">
- <include segmentGroup="axon_0"/>
- <include segmentGroup="axon_1"/>
- <include segmentGroup="dend_0"/>
- <include segmentGroup="dend_1"/>
- <include segmentGroup="dend_2"/>
- <include segmentGroup="dend_3"/>
- <include segmentGroup="dend_4"/>
- <include segmentGroup="dend_5"/>
- <include segmentGroup="dend_6"/>
- <include segmentGroup="dend_7"/>
- <include segmentGroup="dend_8"/>
- <include segmentGroup="dend_9"/>
- <include segmentGroup="dend_10"/>
- <include segmentGroup="dend_11"/>
- <include segmentGroup="dend_12"/>
- <include segmentGroup="dend_13"/>
- <include segmentGroup="dend_14"/>
- <include segmentGroup="dend_15"/>
- <include segmentGroup="dend_16"/>
- <include segmentGroup="dend_17"/>
- <include segmentGroup="dend_18"/>
- <include segmentGroup="dend_19"/>
- <include segmentGroup="dend_20"/>
- <include segmentGroup="dend_21"/>
- <include segmentGroup="dend_22"/>
- <include segmentGroup="dend_23"/>
- <include segmentGroup="dend_24"/>
- <include segmentGroup="dend_25"/>
- <include segmentGroup="dend_26"/>
- <include segmentGroup="dend_27"/>
- <include segmentGroup="dend_28"/>
- <include segmentGroup="dend_29"/>
- <include segmentGroup="dend_30"/>
- <include segmentGroup="dend_31"/>
- <include segmentGroup="dend_32"/>
- <include segmentGroup="dend_33"/>
- <include segmentGroup="dend_34"/>
- <include segmentGroup="dend_35"/>
- <include segmentGroup="dend_36"/>
- <include segmentGroup="dend_37"/>
- <include segmentGroup="dend_38"/>
- <include segmentGroup="dend_39"/>
- <include segmentGroup="dend_40"/>
- <include segmentGroup="dend_41"/>
- <include segmentGroup="dend_42"/>
- <include segmentGroup="dend_43"/>
- <include segmentGroup="dend_44"/>
- <include segmentGroup="dend_45"/>
- <include segmentGroup="dend_46"/>
- <include segmentGroup="dend_47"/>
- <include segmentGroup="dend_48"/>
- <include segmentGroup="dend_49"/>
- <include segmentGroup="dend_50"/>
- <include segmentGroup="dend_51"/>
- <include segmentGroup="dend_52"/>
- <include segmentGroup="soma_0"/>
- </segmentGroup>
- </morphology>
- <biophysicalProperties id="biophys">
- <membraneProperties>
- <channelDensity id="pas" ionChannel="pas" condDensity="2.5756438955642182e-05 S_per_cm2" erev="-79.74132024971513 mV" ion="non_specific"/>
- <channelDensity id="Ih" ionChannel="Ih" condDensity="4.274951616063423e-05 S_per_cm2" erev="-45 mV" ion="hcn"/>
- <channelDensity id="NaTg_somatic" ionChannel="NaTg_VIP_somatic" condDensity="0.11491205828369114 S_per_cm2" erev="50 mV" segmentGroup="soma_group" ion="na"/>
- <channelDensity id="Nap_somatic" ionChannel="Nap" condDensity="0.0001895305240694194 S_per_cm2" erev="50 mV" segmentGroup="soma_group" ion="na"/>
- <channelDensity id="K_P_somatic" ionChannel="K_P" condDensity="0.0009925418924114282 S_per_cm2" erev="-85 mV" segmentGroup="soma_group" ion="k"/>
- <channelDensity id="K_T_somatic" ionChannel="K_T" condDensity="0.009051981253674193 S_per_cm2" erev="-85 mV" segmentGroup="soma_group" ion="k"/>
- <channelDensity id="Kv3_1_somatic" ionChannel="Kv3_1" condDensity="0.31215653649208114 S_per_cm2" erev="-85 mV" segmentGroup="soma_group" ion="k"/>
- <channelDensity id="Im_somatic" ionChannel="Im" condDensity="0.0003679378262289559 S_per_cm2" erev="-85 mV" segmentGroup="soma_group" ion="k"/>
- <channelDensity id="SK_somatic" ionChannel="SK" condDensity="0.1655502166633749 S_per_cm2" erev="-85 mV" segmentGroup="soma_group" ion="k"/>
- <channelDensity id="NaTg_axonal" ionChannel="NaTg_VIP_axonal" condDensity="0.20112200814143477 S_per_cm2" erev="50 mV" segmentGroup="axon_group" ion="na"/>
- <channelDensity id="Nap_axonal" ionChannel="Nap" condDensity="0.0006248906854665301 S_per_cm2" erev="50 mV" segmentGroup="axon_group" ion="na"/>
- <channelDensity id="K_P_axonal" ionChannel="K_P" condDensity="0.26489876414660096 S_per_cm2" erev="-85 mV" segmentGroup="axon_group" ion="k"/>
- <channelDensity id="K_T_axonal" ionChannel="K_T" condDensity="0.014364427062274185 S_per_cm2" erev="-85 mV" segmentGroup="axon_group" ion="k"/>
- <channelDensity id="Kv3_1_axonal" ionChannel="Kv3_1" condDensity="0.0011201608191112877 S_per_cm2" erev="-85 mV" segmentGroup="axon_group" ion="k"/>
- <channelDensity id="Im_axonal" ionChannel="Im" condDensity="0.00013891465461042372 S_per_cm2" erev="-85 mV" segmentGroup="axon_group" ion="k"/>
- <channelDensity id="SK_axonal" ionChannel="SK" condDensity="0.7027792087501376 S_per_cm2" erev="-85 mV" segmentGroup="axon_group" ion="k"/>
- <channelDensityNernst id="Ca_HVA_somatic" ionChannel="Ca_HVA" condDensity="4.384846294634834e-05 S_per_cm2" segmentGroup="soma_group" ion="ca"/>
- <channelDensityNernst id="Ca_LVA_somatic" ionChannel="Ca_LVA" condDensity="0.0034472458995879864 S_per_cm2" segmentGroup="soma_group" ion="ca"/>
- <channelDensityNernst id="Ca_HVA_axonal" ionChannel="Ca_HVA" condDensity="2.819397237794038e-05 S_per_cm2" segmentGroup="axon_group" ion="ca"/>
- <channelDensityNernst id="Ca_LVA_axonal" ionChannel="Ca_LVA" condDensity="0.010354001513952075 S_per_cm2" segmentGroup="axon_group" ion="ca"/>
- <spikeThresh value="10mV"/>
- <specificCapacitance value="2 uF_per_cm2"/>
- <initMembPotential value="-80mV"/>
- </membraneProperties>
- <intracellularProperties>
- <species id="ca" concentrationModel="CaDynamics_E2_NML2_VIP_somatic" ion="ca" initialConcentration="1e-4 mM" initialExtConcentration="2.0E-6 mol_per_cm3" segmentGroup="soma_group"/>
- <species id="ca" concentrationModel="CaDynamics_E2_NML2_VIP_axonal" ion="ca" initialConcentration="1e-4 mM" initialExtConcentration="2.0E-6 mol_per_cm3" segmentGroup="axon_group"/>
- <resistivity value="0.1 kohm_cm"/>
- </intracellularProperties>
- </biophysicalProperties>
- </cell>
- </neuroml>
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