Human-L2-3-Cortical-Microcircuit/NeuroML2/HL23PV.cell.nml

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    <notes> NeuroML 2 file generated from ModelView by: NEURON -- VERSION 8.2.2 release/8.2 (93d41fafd) 2022-12-15
          Authors: Michael Hines, Sushil Kambampati and Padraig Gleeson,
          Yale University and UCL 
  </notes>
    <include href="CaDynamics_E2_NML2.nml"/>
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    <include href="channels/Ih.channel.nml"/>
    <include href="channels/NaTg/NaTg.channel.nml"/>
    <include href="channels/Nap.channel.nml"/>
    <include href="channels/K_P.channel.nml"/>
    <include href="channels/K_T.channel.nml"/>
    <include href="channels/Kv3_1.channel.nml"/>
    <include href="channels/Im.channel.nml"/>
    <include href="channels/SK.channel.nml"/>
    <include href="channels/Ca_HVA.channel.nml"/>
    <include href="channels/Ca_LVA.channel.nml"/>
    <cell id="HL23PV">
        <notes>Cell: HL23PV exported from NEURON ModelView. Reference: Yao, H. K.; Guet-McCreight, A.; Mazza, F.; Moradi Chameh, H.; Prevot, T. D.; Griffiths, J. D.; Tripathy, S. J.; Valiante, T. A.; Sibille, E. &amp; Hay, E.  Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits Cell Reports, Elsevier, 2022, 38</notes>
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                <include segmentGroup="dend_16"/>
                <include segmentGroup="dend_17"/>
                <include segmentGroup="dend_18"/>
                <include segmentGroup="dend_19"/>
                <include segmentGroup="dend_20"/>
                <include segmentGroup="dend_21"/>
                <include segmentGroup="dend_22"/>
                <include segmentGroup="dend_23"/>
                <include segmentGroup="dend_24"/>
                <include segmentGroup="dend_25"/>
                <include segmentGroup="dend_26"/>
                <include segmentGroup="dend_27"/>
                <include segmentGroup="dend_28"/>
                <include segmentGroup="dend_29"/>
                <include segmentGroup="dend_30"/>
                <include segmentGroup="dend_31"/>
                <include segmentGroup="dend_32"/>
                <include segmentGroup="dend_33"/>
                <include segmentGroup="dend_34"/>
                <include segmentGroup="dend_35"/>
                <include segmentGroup="dend_36"/>
                <include segmentGroup="dend_37"/>
                <include segmentGroup="dend_38"/>
                <include segmentGroup="dend_39"/>
                <include segmentGroup="dend_40"/>
                <include segmentGroup="dend_41"/>
                <include segmentGroup="dend_42"/>
                <include segmentGroup="dend_43"/>
                <include segmentGroup="dend_44"/>
                <include segmentGroup="dend_45"/>
                <include segmentGroup="dend_46"/>
                <include segmentGroup="dend_47"/>
                <include segmentGroup="dend_48"/>
            </segmentGroup>
            <segmentGroup id="all">
                <include segmentGroup="axon_0"/>
                <include segmentGroup="axon_1"/>
                <include segmentGroup="dend_0"/>
                <include segmentGroup="dend_1"/>
                <include segmentGroup="dend_2"/>
                <include segmentGroup="dend_3"/>
                <include segmentGroup="dend_4"/>
                <include segmentGroup="dend_5"/>
                <include segmentGroup="dend_6"/>
                <include segmentGroup="dend_7"/>
                <include segmentGroup="dend_8"/>
                <include segmentGroup="dend_9"/>
                <include segmentGroup="dend_10"/>
                <include segmentGroup="dend_11"/>
                <include segmentGroup="dend_12"/>
                <include segmentGroup="dend_13"/>
                <include segmentGroup="dend_14"/>
                <include segmentGroup="dend_15"/>
                <include segmentGroup="dend_16"/>
                <include segmentGroup="dend_17"/>
                <include segmentGroup="dend_18"/>
                <include segmentGroup="dend_19"/>
                <include segmentGroup="dend_20"/>
                <include segmentGroup="dend_21"/>
                <include segmentGroup="dend_22"/>
                <include segmentGroup="dend_23"/>
                <include segmentGroup="dend_24"/>
                <include segmentGroup="dend_25"/>
                <include segmentGroup="dend_26"/>
                <include segmentGroup="dend_27"/>
                <include segmentGroup="dend_28"/>
                <include segmentGroup="dend_29"/>
                <include segmentGroup="dend_30"/>
                <include segmentGroup="dend_31"/>
                <include segmentGroup="dend_32"/>
                <include segmentGroup="dend_33"/>
                <include segmentGroup="dend_34"/>
                <include segmentGroup="dend_35"/>
                <include segmentGroup="dend_36"/>
                <include segmentGroup="dend_37"/>
                <include segmentGroup="dend_38"/>
                <include segmentGroup="dend_39"/>
                <include segmentGroup="dend_40"/>
                <include segmentGroup="dend_41"/>
                <include segmentGroup="dend_42"/>
                <include segmentGroup="dend_43"/>
                <include segmentGroup="dend_44"/>
                <include segmentGroup="dend_45"/>
                <include segmentGroup="dend_46"/>
                <include segmentGroup="dend_47"/>
                <include segmentGroup="dend_48"/>
                <include segmentGroup="soma_0"/>
            </segmentGroup>
        </morphology>
        <biophysicalProperties id="biophys">
            <membraneProperties>
                <channelDensity id="pas" ionChannel="pas" condDensity="0.00011830111773572024 S_per_cm2" erev="-83.92924122901199 mV" ion="non_specific"/>
                <channelDensity id="Ih" ionChannel="Ih" condDensity="2.7671764064314368e-05 S_per_cm2" erev="-45 mV" ion="hcn"/>
                <channelDensity id="NaTg_somatic" ionChannel="NaTg_PV" condDensity="0.49958525078702043 S_per_cm2" erev="50 mV" segmentGroup="soma_group" ion="na"/>
                <channelDensity id="Nap_somatic" ionChannel="Nap" condDensity="0.008795461417521086 S_per_cm2" erev="50 mV" segmentGroup="soma_group" ion="na"/>
                <channelDensity id="K_P_somatic" ionChannel="K_P" condDensity="9.606092478937705e-06 S_per_cm2" erev="-85 mV" segmentGroup="soma_group" ion="k"/>
                <channelDensity id="K_T_somatic" ionChannel="K_T" condDensity="0.0011701702607527396 S_per_cm2" erev="-85 mV" segmentGroup="soma_group" ion="k"/>
                <channelDensity id="Kv3_1_somatic" ionChannel="Kv3_1" condDensity="2.9921080101237565 S_per_cm2" erev="-85 mV" segmentGroup="soma_group" ion="k"/>
                <channelDensity id="Im_somatic" ionChannel="Im" condDensity="0.04215865946497755 S_per_cm2" erev="-85 mV" segmentGroup="soma_group" ion="k"/>
                <channelDensity id="SK_somatic" ionChannel="SK" condDensity="3.7265770903193036e-06 S_per_cm2" erev="-85 mV" segmentGroup="soma_group" ion="k"/>
                <channelDensity id="NaTg_axonal" ionChannel="NaTg_PV" condDensity="0.10914576408883477 S_per_cm2" erev="50 mV" segmentGroup="axon_group" ion="na"/>
                <channelDensity id="Nap_axonal" ionChannel="Nap" condDensity="0.001200899579358837 S_per_cm2" erev="50 mV" segmentGroup="axon_group" ion="na"/>
                <channelDensity id="K_P_axonal" ionChannel="K_P" condDensity="0.6854776593761795 S_per_cm2" erev="-85 mV" segmentGroup="axon_group" ion="k"/>
                <channelDensity id="K_T_axonal" ionChannel="K_T" condDensity="0.07603372775662909 S_per_cm2" erev="-85 mV" segmentGroup="axon_group" ion="k"/>
                <channelDensity id="Kv3_1_axonal" ionChannel="Kv3_1" condDensity="2.988867483754507 S_per_cm2" erev="-85 mV" segmentGroup="axon_group" ion="k"/>
                <channelDensity id="Im_axonal" ionChannel="Im" condDensity="0.029587905136596156 S_per_cm2" erev="-85 mV" segmentGroup="axon_group" ion="k"/>
                <channelDensity id="SK_axonal" ionChannel="SK" condDensity="0.5121938998281017 S_per_cm2" erev="-85 mV" segmentGroup="axon_group" ion="k"/>
                <channelDensityNernst id="Ca_HVA_somatic" ionChannel="Ca_HVA" condDensity="0.00017953651378188165 S_per_cm2" segmentGroup="soma_group" ion="ca"/>
                <channelDensityNernst id="Ca_LVA_somatic" ionChannel="Ca_LVA" condDensity="0.09250008555398015 S_per_cm2" segmentGroup="soma_group" ion="ca"/>
                <channelDensityNernst id="Ca_HVA_axonal" ionChannel="Ca_HVA" condDensity="0.002961469262723619 S_per_cm2" segmentGroup="axon_group" ion="ca"/>
                <channelDensityNernst id="Ca_LVA_axonal" ionChannel="Ca_LVA" condDensity="5.9457835817342756e-05 S_per_cm2" segmentGroup="axon_group" ion="ca"/>
                <spikeThresh value="10mV"/>
                <specificCapacitance value="2 uF_per_cm2"/>
                <initMembPotential value="-80mV"/>
            </membraneProperties>
            <intracellularProperties>
                <species id="ca" concentrationModel="CaDynamics_E2_NML2_PV_somatic" ion="ca" initialConcentration="1e-4 mM" initialExtConcentration="2.0E-6 mol_per_cm3" segmentGroup="soma_group"/>
                <species id="ca" concentrationModel="CaDynamics_E2_NML2_PV_axonal" ion="ca" initialConcentration="1e-4 mM" initialExtConcentration="2.0E-6 mol_per_cm3" segmentGroup="axon_group"/>
                <resistivity value="0.1 kohm_cm"/>
            </intracellularProperties>
        </biophysicalProperties>
    </cell>
</neuroml>