NeuroML conversions of the Yao et al 2022 Human L2/3 cortical microcircuit:

Yao, H. K. et al. Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits. Cell Rep. 38, (2022).



Non git-annex files can also be obtained from https://github.com/sanjayankur31/Human-L2-3-Cortical-Microcircuit/

Ankur Sinha (Ankur Sinha Gmail) bb3e5112ef feat: add arguments to main script 3 月之前
.github c309e751a3 Update versions of actions and install HDF5 for pytables on macos-latest 3 月之前
L23Net a352558d6b fix: define N_cells 7 月之前
NeuroML2 bb3e5112ef feat: add arguments to main script 3 月之前
.flake8 4b296b81fb chore: add flake config 2 年之前
.gitignore 0dde0361da Updated test net 3 月之前
.pre-commit-config.yaml 155a47b08e chore: add pre-commit 3 月之前
README.md 4b970fb588 Add files via upload 2 年之前
lfpy_env.yml 07d31ccf51 Add files via upload 2 年之前

README.md

Human L2/3 Cortical Circuit Model --- Yao-et-al.-2022

============================================================================== Author: Heng Kang yao

This is the readme for the model associated with the paper:

Yao, H. K. et al. Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits. Cell Rep. 38, (2022).

Network Simulations: Simulation code associated with the default L2/3 circuit used throughout the manuscript is in the /L23Net directory.

To run simulations, install all of the necessary python modules (see lfpy_env.yml), compile the mod files within the mod folder, and submit the simulations in parallel. To run the depression condition, set MDD to True.

To run the circuit in parallel, use the following command:

mpiexec -n 400 python circuit.py 1234

The 400 corresponds to the number of CPU and 1234 correspond to the seed.