Snakemake is designed for ease of use, scalability, and reproducibility of scientific workflows. The workflows are written using a Python-inspired language.
Nextflow is a tool designed for scalable and reproducible scientific workflows, ideal for high-throughput data analysis.
Cromwell supports multiple languages and backends, allowing a flexible environment for different scientific needs.
WDL is particularly useful for writing and sharing bioinformatics workflows.
CWL is designed to meet the needs of high-throughput data-intensive science workflows, such as genomics and machine learning.