# Effect of TMS current direction and pulse waveform on cortico-cortical connectivity: A registered report TMS-EEG study


Raw data, dataset and script for the study 'Effect of TMS current direction and pulse waveform on cortico-cortical connectivity: A registered report TMS-EEG study' by Guidali, Zazio, Lucarelli, Marcantoni, Stango, Barchiesi & Bortoletto (2023)

The different folders contains the following materials:

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**'Raw data MEP and TEP' folders**

Folders contains the raw .mat files from g.tech amplifier of every participants (one folder for each participant). Here, each file contains metadata about the sampling rate and the name of the subject (S01, S02, and so on) and the experimental condition, as follows:

Mo_PA = monophasic PA direction

Mo_AP = monophasic AP direction

Mo_LM = monophasic LM direction

Bi_PA = biphasic PA direction

Bi_AP = biphasic AP direction

Bi_LM = biphasic LM direction

Bi_PA_Contr = biphasic PA with ipsilateral hand contracted

MEP recording contains also the specification 'MEP' at the end of the experimental condition name

Folders in Raw data are also timestamped to notify that collection occured after Stage 1 in principle acceptance date

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**'Dataset and analysis' folder**

Contains .omv (for software Jamovi) and .r files (for software R) of the analysis. Name of the file indicates the analysis in that file.

.omv files also contain datasets used for the analysis. 

For analysis conducted using R software, .csv files containing the datasets are provided.

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**'Script preprocessing EMG-EEG' folder**

Contains .m files of the two preprocessing pipelines (TEP and MEP) and the script used for the extraction of M1-P15 values. 

For TEPs, it also contains: 
- a subfolder with datasets with ICA weight files (.set and .fdt file, named as 'subject number and condition' - e.g., S01_Mo_PA; 'step 4.1' indicated the preprocessing pipeline step at which the file had been created)
- a subfolder with .mat files for the number of the ICA components removed - one for each condition with one row for each subject)
- number of trials rejected (one .xls file for the first artifact rejection, i.e., before ICA, and one file for the second - and final - artifact rejection, i.e., at the end of the preprocessing pipeline).

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**'Script task' folder**

Contains .m files of the tasks to trigger TMS pulses in the different experimental conditions. Each file has been commented to provide a step-by-step guide to the different scripts and functions.

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**'Laboratory log' file**

Contains information about time table of the experiment (mandatory for European Journal of Neuroscience).

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**'Subject_info' file**

Contains anonimized demographic and TMS informations (i.e., resting motor threshold for every experimental condition) about the participants of our final sample.

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**'Figures folder'**

Contains a .txt file with information about figures in the manuscript, .m files to reproduce figures made with Matlab

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For additional info contact: 

Giacomo Guidali, PhD - giacomo.guidali@unimib.it

Marta Bortoletto, PhD - mbortoletto@fatebenefratelli.eu